产品货号：
Z10542
中文名称：
AHR抗体
英文名称：
Anti-AHR Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AHR Antibody |
| 指标别名 | Ah receptor;AHR;aryl hydrocarbon receptor;bHLHe76 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC,FCM |
| 基因名称 | AHR |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence of human AHR (AFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHH). |
| 实际分子量 | 100KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | AHR (aryl hydrocarbon receptor),also called bHLHe76,is a member of the family of basic helix-loop-helix transcription factors.AhR is a cytosolic transcription factor that is normally inactive,bound to several co-chaperones.The AHR gene is mapped on 7p21.1.Estrogenic actions of AHR agonists were detected in wildtype ovariectomized mouse uteri,but were absent in Ahr -/- or Er-alpha -/- ovariectomized mice.Complex assembly and ubiquitin ligase activity of CUL4B(AHR) in vitro and in vivo are dependent on the AHR ligand.In the CUL4B(AHR) complex,ligand-activated AHR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation.Cd4-positive cells from mice lacking Ahr developed Th17 responses but failed to produce Il22 and did not show enhanced Th17 development.Activation of Ahr during induction of EAE accelerated disease onset and increased pathology in wildtype mice,but not in Ahr -/- mice.The TDO-AHR pathway is active in human brain tumors and is associated with malignant progression and poor survival.Ahr activity within ROR-gamma-t-positive ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae. |
| Uniprot ID | P35869 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section 1:50～400 Immunocytochemistry in fixed cells 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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